Zinc is an essential trace element and plays essential roles in metabolisms from human and animal organism. But over-doses of zinc can translocate other metals and disturbing the minerals’ homeostasy. This experiment presents the concentration of some trace elements (Cu, Mn) and potential toxic metals (Al, Pb) after administration of zinc over-doses compare to Recommended Daily Intake (RDI), analyzed from brain of Wistar strain rats. We had three experimental groups and we administrated by gavage ZnCl2 solution (2xRDI for Zn) at rats from E1 group, ZnCl2 solution (4xRDI for Zn) for E2 group and tap water for control group (C). After experiment, concentration of Cu (3.42±0.79µg/g for E1 and 2.40±0.45µg/g for E2), Mn (0.54±0.16µg/g for E1 and 0.53±µg/g for E2), Al (3.69±1.05µg/g for E1 and 3.72±1.18µg/g for E2) and Pb (undetectable for E1 and E2), decrease at experimental groups (E1 and E2) compare to control group (Cu 3.98±0.97µg/g, Mn 1.25±0.60 µg/g, Al 6.17±1.76 and Pb 0.52±0.17 concentrations for control group).
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