After administration of cisplatin, biochemical homeostasis is affected. Cisplatin has been an important chemotherapeutic agent used in treatment of cancer. This paper is trying to reveal the modification of some elements: Mg, Ca, Fe Na, and K, from blood after intraperitoneal administration of cisplatinum, to Wistar rats. The drug was administrated in doses 2 mg/kg b.w. and 8 mg/kg b.w. The results of these experiment shows that concentration of magnesium and calcium from total blood, and the sodium concentration from blood serum are decreased proportionally with the administrated doses; concentration of iron from total blood and potassium from serum blood are increased.
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