Authors:
Dimple Agnihotri, Arpita Mukherjee, Dipan Adhikari
Volume 31, Issue 1;
Pages: 81-110; 2025
ISSN: 2069-0053 (print), Agroprint
ISSN (online): 2068-9551
The medicinal plant Cassia fistula L., sometimes referred to as Amaltas or Golden Shower, is widely distributed in India. In this study examination of the phytochemical makeup of Cassia fistula L., vegetative parts, viz., leaf and pod for its antibacterial efficacy against a variety of bacteria that were frequently linked to infection in addition to genotoxic cum mitodepressive potential of the pod against Cassia fistula L., root tip cells were taken up. The extracts were subjected to phytochemical analysis and antibacterial activity with the well diffusion method. The extracts from Cassia fistula L. contained a range of phytochemicals, including as phenolics, terpenoids, flavonoids, and alkaloids. The methanol extract exhibited the strongest antibacterial action. Additionally, out of these five different extracts of Cassia fistula L., dried pod aqueous and methanolic extract exhibited maximum inhibitionof normal mitotic index (MI) and maximum production of genotoxicity index (GenI) in growing root tip cells of Cassia fistula L., and there were statistically significant differential responses in terms of electrolyte leakage (the potency of electrolyte being: Aqueous extract>Methanolic extract>Ethanolic extract>acetone extact>Petroleum Ether extract in comparison to control sets) coupled with attenuation cum inhibition of root dehydrogenase activity (mitochondrial activity) in root tip cells of Cassia fistula L., (Aqueous and methanolic extract of Cassia fistula L., pod powder produced maximum inhibition of dehydrogenase acitivity and subsequent mitochondrial poisoning in comparison to Ethanolic, Chloroform and Petroleum Ether Extracts in the same doses) indicating probable cytotoxic cum metabolic inhibitory activities as at higher doses, which may be utilized further for drugs for greater phytoremidiation. Cassia fistula L., may be utilized to create fresh antibacterial medications and as a natural supply of antibacterial chemicals.
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