Antibacterial activity of Hypericum (Hypericaceae) species against Gram-positive bacterial isolates

Authors:

B. Saleh, M. Khawajkiah, A. Almariri

 

Volume 29, Issue 4;
Pages: 295-303; 2023
ISSN: 2069-0053 (print), Agroprint;
ISSN (online): 2068-9551

Abstract:

Antimicrobial activity of three Hypericum species widely distributed in Syria including H. triquetrifolium Turra, H. thymifolium Banks & Sol, and H. perforatum L. species has been evaluated using aqueous, methanol, chloroform and diethyl-ether solvents against eight Gram-positive bacterial isolates. Antibacterial test has been performed based on zone of inhibition (ZI), minimum inhibition concentration (MIC), minimal bactericidal concen­tration (MBC) determination and time-kill kinetic assays. Data revealed that the diethyl-ether H. triquetrifolium areal parts extracts showed the highest antibacterial activity by showing the highest ZI value of 16.3 mm and the lowest MIC & MBC values of 0.03 and 0.06 µg/mL against Streptococcus faecalis. Allover, diethyl-ether H. triquetrifolium, methanolic H. thymifolium and methanolic H. perforatum extracts were strongly active against all tested bacterial isolates. Whereas, aqueous Hypericum species extracts were non active against all tested bacterial isolates, regardless tested Hypericum species. Moreover, Time-kill kinetics test revealed that methanolic H. thymifolium extracts exhibited bacteriostatic action. Further performance studies regarding diethyl-ether H. triquetrifolium, methanolic H. thymifolium and methanolic H. perforatum extracts are requested

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