The in vitro Toxicological Potential of Lactobacillus paracasei on Detroit 562 Pharyngeal Cancer Cells


Robert Cosmin Racea, Doina Chioran, Alina Anton, Stefania Dinu, Roxana Buzatu, Mircea Rivis


Volume 29, Issue 1;
Pages: 16-22; 2023
ISSN: 2069-0053 (print), Agroprint;
ISSN (online): 2068-9551


Head and neck cancer (HNC) is a frequent malignancy encountered around the world. The lifestyle, including the consumption of cigarettes and alcohol, represent some of the major causes of this cancer, and the approach of appropriate behavior could significantly improve the situation. The consumption of food supplements is in trend, to balance the intake of nutrients. Probiotics (PBT) are more and more frequently used, due to their multiple properties. The aim of this study was to analyze the effect of Lactobacillus paracasei on the Detroit 562 human pharyngeal cancer cell line. The results bring out an important impact, observed in the reduction of cell viability, as well as the reduction of cell confluence. These data highlight the potential of the probiotic on the tested line, however, additional data are needed for the complete usefulness of the PBT in order to use it as a co-treatment in case of pharyngeal cancer.

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