Assessment of the cytotoxic potential of rutin formulations on human oral cells


Denisa Predut, Alina Dolghi, Cristina Grosu, Bociort Flavia, Andrada Iftode, Anca Jivanescu

Volume 28, Issue 4;
Pages: 305-309; 2022
ISSN: 2069-0053 (print) (former ISSN: 1453-1399), Agroprint;
ISSN (online): 2068-9551


Rutin is a bioflavonoid found mostly in medicinal plants, but also in food, and other products. Throughout the years, rutin has been proven to exhibit important pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer activities. Due to its low oral solubility, the flavonoid is preferable to be included in nanoformulas. The main aim of the present study was to assess the cytotoxic potential of rutin and rutin formulations on one healthy cell line (primary gingival keratinocytes - PGK) and two tumoral oral cell lines (tongue carcinoma - SCC-4 and pharynx carcinoma - Detroit 562). The in vitro assay employed was MTT test which revealed that rutin has a cytotoxic effect on cancer cells, without affecting the healthy ones, and its inclusion in liposomes increases its anticancer potential, especially at 10 and 25µM. The results warrant further detailed studies and in-depth anti-cancer mechanistic research.

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