Therapeutic activity of fermented camel milk with Artemisia absinthium on alloxan induced diabetic rats

Authors:
Mahmoud M. Motawee, Hesham Z. Tawfeuk

Volume 27, Issue 2;
Pages: 219-229; 2021
ISSN: 2069-0053 (print) (former ISSN: 1453-1399), Agroprint;
ISSN (online): 2068-9551
Abstract:
The aim of the present study was to investigate the therapeutic effect exerted by fortified fermented camel milk (FCM) with Artemisia absinthium (AA) on alloxan-induced diabetic rats. The anti-diabetic and antioxidant effect of FCM and AA aqueous extract were studied in diabetic rats model. Fifty male Sprague-Dawley rats weighing 200±20 g were divided into five groups. The first group kept as negative control (-ve) group (n= 10 rats) which fed on basal diet only. The rest of rats were injected with a single intraperitoneal dose of alloxan (120 mg/kg bw) to induce diabetes. Diabetic rats were divided into 4 groups that were positive control +ve and 3 treated groups that were fermented camel milk(FCM) , Artemisia Absinthium aqueous extract(AA) and mixed with them (FCM +AA). Results showed that consumption of (FCM) with aqueous extract(AA)group showed improvement of serum glucose, (ALT and AST), serum protein levels (total proteins, albumin, globulin and A/G ratio), oxidative stress marker (CAT, SOD MDA, GSH, NO and 8OHdG), Results showed that alloxan significantly (P≤0.05) disrupted glucose level, induced oxidative stress. In contrast treated group with FCM in combination with AA showed optimum protective effect to near control level compared to the individual treatments. The study suggested that, the mixture of FCM plus AA aqueous extract had a protective activity likely due to stimulation of pancreatic β-cells leading to insulin secretion. The study recommended that the combination of FCM and AA extracts rich polyphenols as antioxidant and activate insulin secretion.
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