Assessment of the biological activity of thyme essential oil in the presence of the classic antibiotic tetracycline

Daniel F. Pancu, Raluca Milutinovici, Roxana Buzatu, Alina Dolghi, Marioara Poenaru

Volume 27, Issue 2;
Pages: 190-194; 2021
ISSN: 2069-0053 (print) (former ISSN: 1453-1399), Agroprint;
ISSN (online): 2068-9551
The present study was purported to assess the activities: (i) antibacterial and synergistic against three types of both gram-positive and gram-negative bacteria that are susceptible to drug resistance and (ii) cytotoxic and synergistic on colorectal adenocarcinoma cells, of thyme essential oil in combination with tetracycline. Antibacterial and synergistic properties were determined by disk diffusion method and cytotoxic activity by quantifying viable cells by using MTT assay. Thyme essential oil has antibacterial activity against both gram-positive and gram-negative bacteria, especially on S. aureus and K. pneumoniae at the highest concentration tested, having also a synergistic effect when combined with tetracycline. Essential oil-treated cells showed a dose-dependent reduction in colorectal adenocarcinoma cell viability, while combination with tetracycline leads to a significantly attenuated decrease in viability
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