Bacillus has become the bacterium of the choice for its versatility and capacity to synthesize hydrolytic enzymes and release extracellular antifungal metabolites. In this work, out of 525 isolates, the Bacillus isolate SY123A was the best xylanase and amylase producer (391.38 U/g; pH 7.0 and 195.46 U/g; pH 6.0, respectively) through solid-state fermentation (SSF), which was associated with high antagonistic activities (up 100%) against four common and destructive soil- borne phytopathogenic fungi in nutrient agar (NA) medium. According to the colony morphology and 16S rRNA gene sequencing, the isolate was identified as B. amyloliquefaciens. The biotechnological potential of SY123A could suggest this isolate as very promising for agro-industry and the environmental aspect.