In vitro experimental evaluations of birch bark extracts with selectivity in the obtaining of betulinol

Marius Preda, Eugen Sisu, Vicentiu Vlaia, Tudor Olariu, Alina Moaca, Livia-Cristina Borcan, Florin Borcan

Volume 24, Issue 4;
Pages: 289-294; 2018
ISSN: 2069-0053 (print) (former ISSN: 1453-1399), Agroprint;
ISSN (online): 2068-9551
The modern and sedentary human organism exposed to excessive pollution often feels an acute need for antioxidant vitamins which can prevent various types of cancer. But once the disease has been established, it can be combated with a series of remedies made available by natural medicine, with many plants whose anti-cancer role has been proved. The aims of this research were to develop some birch bark extracts with different betulinol purity and to evaluate their activity on three cells line: the epidermoid carcinoma cells - A431 and the cells of mammary adenocarcinoma - MCF7 and MDA-MB-231; the cells viability evaluation was based on Alamar blue method. The results of this study indicate a dose-dependend stimulative activity of extracts on cancer cells.
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