Citrus X paradisi (CP), Camelia sinensis (Green tea – GT) and Hypericum perforatum (HP) are natural products with antioxidant properties commonly used in traditional medicine as alternative treatments for various chronic disorders including cardio-vascular diseases, diabetes and cancer. The aim of this study was to evaluate: a) the antioxidant properties of CP, GT (ethanolic extract and infusion) and HP extract using DPPH method and b) the anti-migratory effects of CP, GT and HP extracts on B164A5 murine melanoma cells using scratch assay technique. Our results indicated that the CP, the GT and the HP extracts had shown potent antioxidant effects and a slight anti-migratory effect on B164A5 murine melanoma cells.