Fatty acids are essential for energetic, metabolic, and structural activities in the body. In the management of renal disease, nutrition has a central role. The declinations of renal function are influenced by dietary intake of calories, phosphorus, sodium, potassium, protein, or acid load in most of the clinically observable abnormalities. More, the renal system is susceptible to self-perpetuating injury, an inherent property of kidney and the extent of this injury may be modified by adjustments in dietary intake of phosphorus and polyunsaturated fatty acids. Furthermore, continued researches are important for clarification of controversies concerning the impact of dietary n-3 fatty acids in all types of renal diseases.