Spirulina, a water blue-green microalga, is considered a complex natural product that is widely used in treatment of chronic diseases including cancer, hypercholesterolemia, arterial hypertension, obesity and diabetes. Phycocyanin from spirulina is considered to be a strong radical scavenger (hydroxyl, peroxyl and alkoxyl radicals) providing significant antioxidant and anti-inflammatory effects. The aim of this study consists in the evaluation of the anti-inflammatory effect of SP in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation in hairless SKH1 mice. The ears of mice treated with a higher concentration of SP (1000 μg/mL) showed a significant reduction of the inflammatory process than those treated with a smaller concentration of SP (200 μg/mL). Consequently, spirulina has proved dose-dependent anti-inflammatory effects in controlling and, also, in improving the acute inflammation process in mice, being a future alternative therapy for treating inflammation diseases.
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