Plastic packaging materials coming in food contact applications are evaluated for overall migration as per USFDA, EEC, and BIS. In latest modification of EEC directives distilled as aqueous food simulant has been replaced by 10% ethanol. Hence, in the present study we have investigated the difference between distilled water & 10% ethanol as aqueous food simulant with respect to overall migration of commercial packaging films LDPE, HDPE, PP, PET & PS under all the conditions of the time and temperature as per USFDA, EEC, and BIS standards. Overall migration values for aqueous foods under simulating test conditions from frozen to boiling/retort condition, varied differently for specific packaging films: LDPE (0.35-0.57 mg/dm2), HDPE (0.36-0.61 mg/dm2) PP (0.13-1.23 mg/dm2) PET (0.26-1.35 mg/dm2) & PS (0.25-0.46 mg/dm2) respectively. All these values were significantly lower than the specified maximum limit (10 mg/dm2) as per international standards. The results suggest that there was statistically significant difference (p≤0.05) under frozen condition to boiling/retort temperature between distilled water & 10% ethanol. The obtained overall migration values for all samples as per different standards can be attributed to the influence of the solvent and time-temperature used conditions. Further IR of the migration additives proved to be same component in distilled water and 10%ethanol. Our results clearly suggest that either of the above two simulant will be suitable for aqueous non-acidic food.