This study is focused on the modeling migration from packaging materials used in food industry from a polyethylene film to a food simulant. We tried to develop a prediction statistical mathematical model, by performing an evaluation of influence of the effect of three parameters through an analysis of multiple correlations between overall migration concentration as the dependent variable, and the temperature and time as independent variables. This method could reduce the time and costs of the experimental work associated to the analysis by means of a tool with a wide prediction capacity.