Poly(ether urethane) (PEU) copolymers were chosen as drug carriers. The technique of polycondensation combined with spontaneous emulsification using lysine diisocyanate ester (LDI) and different ratio of diols-polyethylene glycol mixture, was used to synthesize PEU drug carriers. After the optimization of the work procedure, there were obtained nanostructures with diameters between 100-500 nm, which were characterized by pH, size and Zeta potential. The determination of toxicological character of these drug carriers was studied using a novel technique based on the skin mouse model. There were applied PEU drug carriers suspensions on C57BL/6 mice skin (topic application) and there were analyzed the changes of skin parameters using noninvasive procedures (tewametry, mexametry, skin-pH measurements). No significant modification was reported. According this data, these PEU materials can be used for further application in the field.
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