Interactions between food packaging materials and chemical compounds of food are of interest for human
nutrition, physiology, biochemistry and xenobiochemistry. In certain situations the chemical constituents of
the packaging materials may interact with food nutrients and/or non-nutritive ingredients of food. Such
situations are dependent on storage conditions, storage duration, processing technologies etc. The chemical
constituents of packaging materials which migrate in food may cause after the consumption
pathophysiological and pathobiochemical problems. From this point of view is important to know their
interaction mechanisms with nutrients are more specifically with tissular bioconstituents.
Biotransformation aspects, specific for xenobiochemistry, of bisphenol A used to manufacture
“polycarbonate” plastic and epoxy resin lignins of food and beverage cans (packaging materials) are
evidenced in this paper. In this context details on the biotransformation, i.e. xenobiosynthesis of bisphenol
A in the organism are given.
Bisphenol A released from polycarbonates of packaging materials and introduced mainly by food intake in
the human organism can interact with various substances. Thus, bisphenol A first is glucuronidated (i.e.
conjugated with glucuronic acid and/or sulphonic derivatives) and then after may be adducted (DNA is
implied by the guanine component). Knowledge of these specific interactions and the consecutive harmful
effects and allow to understand the pathobiochemical mechanisms.
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