The aim this study was to assess how much could modulation of neural reactivity by natural herbal anxiolithics and antidpressants interfere with pathological nociception and subsequent life s quality of these patients. Material and Methds: 15 patients 7 men and 8 women, age between 35-80 years, diagnosed with IBS and treated with trimebutine with no satisfactory control of symptoms undertook this trial after obtaining of informal consent. Patients were treated with usual same dosage trimebutine plus mebeverine and a mixture of natural anxiolithics and antidepressants as herbal extracts such as: Withania Somnifera 125 mg, Centella Asiatica 100 mg, Valeriana Valichii 50 mg, Hypericum Perforatum, 25 mg, by oral administration 2x1 capsules/day, for 3 months. Global wellbeing and pain scores have ben assessed (Mc Gill part A and B quesionnary from 0 - 10 points), before and after 3 months of treatment. Reults: Previous treatment assessmnent of the global scoring was=6,67±0,62 and abdominal pain score was=4,33±0,82.After 3 months of treatment reassessment of scoring found these new data: global scoring was improving =7,33±0,62(p=0,0069,statistic signifficant) and abdominal pain score=3,80±0,77(p=0,0787, no statistic signifficance improvement). Conclusions: Natural mixture of anxiolithics and antidepressants was very efficient on improving quality of life and wellbeing status but not so much with respect to abdominal pain in patients with IBS.These data suggests that these kind of remedies act mostly as modulators on central processing of information and less on the local nociception per se.
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