In vivo evaluation of cyclodextrin complexes

Authors:
Ofelia Cerga (Vlaston), Florin Borcan, Elena Bernad, Iuliana Popovici

Volume 18, Issue 2;
Pages: 130-135;
ISSN: 2069-0053 (print) (former ISSN: 1453-1399), Agroprint;
ISSN (online): 2068-9551
Abstract:
Oleanolic and ursolic acids, two pentacyclic triterpenes with a well-known antitumor activity, are usually easy extracted from many plants. An important deficiency of these two acids with high molecular weights is the low water solubility. In one of our previous paper, we reported the synthesis of inclusion complexes between these acids and hydroxypropyl-beta-cyclodextrin and hydroxypropyl-gamma-cyclodextrin, which were analysed by DSC and X ray diffractometry. In this paper the same products were in vivo evaluated using the tumor murine model with skin chemical cancer initiated with 7,12-dimethylbenz(a)anthracene and proliferated with 12-O-tetradecanoyl-phorbol-13-acetate. The influence of cyclodextrins complexes were monitored with Courage-Khazaka skin probes for transepidermal water loss, pH, sebum, melanin, erythema, and stratum corneum moisture level measurements. The research shows good results in the case of ursolic acid based complexes.
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