This paper presents the evaluation of water content of oxicam/cyclodextrin complexes by classical Karl
Fischer titration; the two-component technique on a Karl Fischer 841 Titrando apparatus (Metrohm) was
used. The total water concentration was in the range of 7.2-9.2%, 9.9-11.1%, and 5.4-9% for the α-
cyclodextrin complexes, β-cyclodextrin complexes and 2-hydroxypropyl-β-cyclodextrin complexes
respectively. However, for β-cyclodextrin complexes two types of water molecules could be evaluated:
“surface” water, which is extracted and reacts with a higher rate, and “strong-bonded” water molecules,
which is extracted and reacts with a lower rate in the titration process. These results are in good agreement
with the thermogravimetric analysis.