Water content of oxicam/cyclodextrin nanoparticles

Authors:
Lenuţa - Maria Suta, Lavinia Vlaia, V. Vlaia , Nicoleta G. Hădărugă, Daniel I. Hădărugă, C. Mircioiu

Volume 17, Issue 4;
Pages: 419-427;
ISSN: 2069-0053 (print) (former: ISSN:1453-1399), Agroprint;
ISSN (online):2068 – 9551

This paper presents the evaluation of water content of oxicam/cyclodextrin complexes by classical Karl Fischer titration; the two-component technique on a Karl Fischer 841 Titrando apparatus (Metrohm) was used. The total water concentration was in the range of 7.2-9.2%, 9.9-11.1%, and 5.4-9% for the α- cyclodextrin complexes, β-cyclodextrin complexes and 2-hydroxypropyl-β-cyclodextrin complexes respectively. However, for β-cyclodextrin complexes two types of water molecules could be evaluated: “surface” water, which is extracted and reacts with a higher rate, and “strong-bonded” water molecules, which is extracted and reacts with a lower rate in the titration process. These results are in good agreement with the thermogravimetric analysis.