Syntheses of new cyclodextrin complexes with oleanolic and ursolic acids

Ofelia Cerga, Florin Borcan, Rita Ambrus, Iuliana Popovici

Volume 17, Issue 4;
Pages: 405-409;
ISSN: 2069-0053 (print) (former: ISSN:1453-1399), Agroprint;
ISSN (online):2068 – 9551
Oleanolic acid (OA) and ursolic acid (UA) are triterpene acids with a well-known antitumor activity. The obtaining procedure (easy extractions from many plants) is an explanation for the large number of studies on their anti-inflammatory, antiviral, hepatoprotective activity, hair and photo-aged skin treatments. The low water solubility of pentacyclic triterpenes, which determine their low bioavailability, is a problem which can be solved by the complexation with cyclodextrins (CDs). In this study OA and UA inclusion complexes were prepared using two different CDs: hydroxy-propyl-beta-cyclodextrin (HPBCD) and hydroxy-propyl-gamma-cyclodextrin (HPGCD) and kneading as complexation procedure. The products were analysed by differential scanning calorimetry and X ray diffractometry and it can be concluded that the complexation with CDs is a good pathway to increase the OA and UA bioavailability.
300645-Timisoara, Calea Aradului 119, Romania
Tel: +40-256-277423
Fax: +40-256-277326
Copyright © 2023 Journal of Agroalimentary Processes and Technologies