Synthesis and characterization of a polyurethane transdermal carrier for lupeol

Authors:
L. M. (Crăciun) Redes, F. Borcan, D.Ionescu, R Ambrus, A. Galuscan, I. Popovici

Volume 17, Issue 3;
Pages: 321-325;
ISSN: 2069-0053 (print) (former: ISSN:1453-1399), Agroprint;
ISSN (online):2068 – 9551

A few polyurethane (PUR) copolymers were recently considered as possible material in the drug delivery systems domain. This study intends to obtain a transdermal carrier for lupeol. PUR nanocapsules were synthesized by interfacial polycondensation combined with spontaneous emulsification. An organic phase containing lysine diisocyanate ester in water-miscible solvent (acetone) and a homogeneous aqueous phase formed by water, diols, polyether and a surfactant (Tween®20) were used in the synthesis. After the optimization of the work procedure, was obtained around 600 nm size nanocapsules which were characterized by pH, size and zeta potential measurements, SEM and DSC and no significant modifications compared with an ethalon were reported