The aim was assessment of efficiency of probiotic treatment versus oral antibiotics on hepatic encephalopathy in patients with nonalcoholic liver cirrhosis. Main results: The group with probiotics provided by natural yoghurt supplement had a significant reduction of time necessary to complete number connection test (NCT)-B from baseline mean time=315,08±22,78 seconds to final mean time = 294,4 ± 18,1seconds(p<0,01).The second group who receive oral antibiotics also showed a significant reduction mean time necessary to complete NCT-B: from baseline 312,6±22,44 seconds to 292±20,56 seconds (p<0,01). There was no significant statistically difference between the group with probiotic treatment versus the group with antibiotics: 294,4±18,1 sec versus 292±20,56 sec (p=0,6633). NCT-A for the both groups was under the cut-off value(78 sec): 51,44±7,32 versus 51,4±6,92(p=0,9842). In conclusions we noted a significant improvement of psychometric tests in patients receiving probiotics comparable to those with oral antibiotics with mitigation of neurocognitive dysfunction.
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