Lupeol as anti-inflammatory compound tested on Balb/c - TPA Model

Authors:
Lavinia Redeş (Crăciun), Daniela Ionescu, Adriana Kaycsa, Sorina Ciurlea, Florin Borcan, B. Rădoi, Iuliana Popovici

Volume 17, Issue 2;
Pages: 157-162;
ISSN: 2069-0053 (print) (former: ISSN:1453-1399), Agroprint;
ISSN (online):2068 – 9551

Lupeol, a pentacyclic triterpene present in many vegetable structures, is a biologically active compound that has been reported to possess a number of pharmacological properties in the in vivo and in vitro studies. In this study, we investigated the antiinflammatory activities of lupeol on 12-O-tetradecanoylphorbol-13-acetate (TPA) induced inflammatory processes on mouse model - skin and ear. The inflammation evolution was tested using Mexameter, Tewameter and skin pH-meter and by histological evaluation.