Our study aims to assess the rheological parameters and toxic effects for some applications of semisolid formulations that include in their composition surfactants: Sodium lauryl sulphate, Tween 20, Sucrose laureate. In laboratory the determinations were performed using a rheometer in standard conditions provided by regulations and on the other hand the clinically toxic side effects were investigated with aid of three groups of healthy volunteers aged 20-30 years using the patch-test application. Sodium lauryl sulfate represents the surfactant determining the best rheological properties (flow viscosity) compared with the other two but laureate sucrose can lead to qualitative rheological formulations.
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