New liposomes containing cobalt ferrite nanoparticles:synthesis and characterization

Nicoleta G. Hădărugă, Daniel I. Hădărugă, Paulina Vlăzan, Lucian Barbu-Tudoran

Volume 17, Issue 1;
Pages: 1-6;
ISSN: 2069-0053 (print) (former: ISSN:1453-1399), Agroprint;
ISSN (online):2068 – 9551
The paper presents an adapted ultrasonication method for obtaining new liposomes with higher bioavailability containing magnetic nanoparticles, with possible applications in treatment of cancer or other diseases which imply cellular targeting. Natural soybean lecithin and magnetic cobalt ferrite nanoparticles were used for obtaining the liposome nanocapsules; these liposome nanocapsules were evaluated and analyzed by transmission electron microscopy (TEM). Generally, the liposomes have not a higher uniformity, being formed by agglomerated capsules with various diameters up to 1000 nm, as is revealed by TEM analysis. The presence of magnetic nanoparticles (dimensions of 8-10 nm) of cobalt ferrite in the liposomes is also demonstrated. The fractionation by centrifugation conduct to more uniforms fractions with diameters of 500-1000 nm for the first fraction, more concentrated in cobalt ferrite nanoparticles, and with lower diameters (200-700 nm) for the second fraction.
300645-Timisoara, Calea Aradului 119, Romania
Tel: +40-256-277423
Fax: +40-256-277326
Copyright © 2023 Journal of Agroalimentary Processes and Technologies