Using of animal models in the study of the effects induced by chemical xenobiotics is of great importance in life sciences and in the bioscience-food science relationship. Experimental investigations on animal models (predilectly mammals), i.e. in vivo, allowed to elucidate the specific molecular mechanisms of “nutrients” metabolization, respectively of “xenobiotics” biotransformation, and the possible interactions among their intermediate products (“metabolites”, respectively “xenobioderivatives”) some of them with implications in pathogenesis. On the whole, such studies are of interest for metabollomics.
Among the studied xenobiotics there are also included the organometallic compounds concerning metallomics. Investigations on the organo-metallic compounds are of special interest in researches having application in the study of cytostatic chemotherapeutics.
Studies on animal models of the known xenobiotics in the bio-anorganic chemistry had in view the effects induced by non-nutritive compounds, synthetic chemotherapeutics, some cosmetic ingredients etc. In this framework there are discussed the characteristic effects triggered by xenobiotics of food interest and pharmaceutical interest. In the peculiar case of organo-metallic compounds one can have a view on their effects on the biochemical homeostasis, on the status of the hematopoietic system and even on the morphology of various tissues.
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