Lupeol, a pentacylcic triterpene that reduces the lesions and irritability on murine skin and is effective on in vitro tumor models

Authors:
Sorina Ciurlea, Daniela Ionescu, Lavinia Craciun (Redes), Codruta Soica, Camelia Peev, Iuliana Popovici

Volume 16, Issue 4;
Pages: 427-432;
ISSN: 2069-0053 (print) (former: ISSN:1453-1399), Agroprint;
ISSN (online):2068 – 9551

Melanoma and lupeol are two aspect that could have a common knowledge because of the activity of pentacyclic triterpene in the mentioned pathology. It has also been shown that lupeol induces differentiation of mouse melanoma cells. The aim of present study was an evaluation of topical active compound lupeol on an experimental chemical melanoma and an in vitro evaluation on sensitive cells such as HeLa (cervix carcinoma) and A431 (skin carcinoma). The methods used specific cells and animals like mice C57BL/6J. The measurements and evaluation included histopathological aspect and erythema evaluation using a Mexameter MX18. The main results indicated an important antitumor activity of lupeol both in vivo and in vitro.