A comparative study regarding melanoma activity of Betulinic acid on topical ointment vs. systemic nanoemulsion delivery systems

Authors:
Sorina A. Ciurlea, Cristina A. Dehelean, Daniela Ionescu, Szilvia Berko, Erszebet Csanyi, Daniel I. Hadaruga, Srinivas Ganta, Mansoor M. Amiji

Volume 16, Issue 4;
Pages: 420-426;
ISSN: 2069-0053 (print) (former: ISSN:1453-1399), Agroprint;
ISSN (online):2068 – 9551

Betulinic acid is an important antitumor compounds that is involved in preclinical and toxicological tests. It proved an selective antitumor activity and also it is an effective compound in nevi treatment. Melanoma is a fatal disease and intervention in early phases could be helpful to reduce its evolution. The most important tests are non invasive type for topical evaluation and histopathological for systemic administration. Mexameter can apreciate the evolution of melanin and haemoglobin. Histopathological evaluation underline pathological events such as metastatic process. The aim of present work was the observations regarding betulinic acid activity on topical and systemic application. The main conclusion is that it is effective both on topical experimental nevi and metastatic melanoma in early stages.