Probiotics available as dietary supplements, acting as “friendly bacteria” are known and used from ancient times for their beneficial effects. According to recent studies reports there is encouraging evidence for use of probiotics in many situations among them being irritable bowel syndrome(IBS), a functional condition where efficacy of current therapeutic options is not yet satisfactory. Present study was an open label prospective randomized study focused on a cohort of constipation predominant IBS patients receiving two kind of probiotic products for 3 months period. We assessed the severity of symptoms prior and after probiotic treatment. Our study has shown that some major symptoms such as: abdominal pain, bowel habit disturbances, flatulence were significantly improved after taken probiotics.