Birch tree is widely spread in Romania being known for a very long time for its healing properties: antiviral, anti-inflammatory, antiallergenic, antihypoxic, hepatoprotector, hypolipemic. The main compound of the birch bark is betulin, a pentacyclic triterpene, which can be easily converted to betulinic acid, a pharmacological more active compound. The purpose of the present study was to underline 2 different possibilities of extraction, well known even on agro-alimentary field and the evaluation of their in vitro activity on a specific cell line: A2058 (human melanoma) comparing with a known antimelanoma compound betulinic acid.