Quercetin and rutin/2-hydroxypropyl-β-cyclodextrin nanoparticles: obtaining, characterization and antioxidant activity

Authors:
Georgeta Coneac, Eliza Gafiţanu, Nicoleta G. Hădărugă, Daniel I. Hădărugă, Adrian Riviş, Dorel Pârvu

This paper presents the obtaining, characterization and antioxidant activity evaluation of quercetin/2-hydroxypropyl-β-cyclodextrin and rutin/2-hydroxypropyl-β-cyclodextrin complexes. For synthesis the crystallization from ethanol-water solution method was used, but the yields were relatively low (up to 23%). The morphology and dimensional characterization was realized by using scanning electron microscopy. The formation of complexes was revealed by differential scanning calorimetry and the antioxidant activity of nanoparticles comparatively with the nonencapsulated quercetin and rutin clearly indicate the controlled release capacity of flavonoids from complexes.