Serum and tissue levels of calcium after cis-platinum administration in wistar rats

Ariana – Bianca Velciov, Mirela Ahmadi-Vincu, P.-R. Velciov, Z. Gârban
The Although cis-platinum is known as one of the most commonly used antineoplastic agent in the treatment of cancer, his mechanism of action is still unclear. Cis-platinum, like most other chemotherapeutic drugs interacts with DNA to inhibit vital cell processes such as replication and transcription. Literature data show that cis-platinum administration affects the biochemical homeostasis of organism. Therefore the purpose of this study was to evaluate differences in some routine laboratory values during cis-platinum administration on tumor free Wistar rats.

For this experiment, we used adults animals from Wistar rats strain divided in two experimental groups and one control group. Wistar rats from the experimental groups were injected intraperitoneally (i.p.) with cis-platinum (the drug called Sin-Platinum) in study days 5 and 10. The animals from control group were injected with physiological solution, also in study days 5 and 10. Blood and tissues samples were collected on 15th days. The animals from experimental groups had lower calcium levels compared with control group. The results showed accumulation of cis-platinum in several different samples, (in this experiment blood samples, muscles and heart tissues) and we evaluated the modifications which appeared after repeated doses simulating chemotherapeutic treatment in tumor-free rats.
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