Xenobiochemical interconditioning in recombinant DNA technology: theoretical and applicative aspects

Zeno Garban, Adina Avacovici
In the technology of recombinant DNA, as a specific domain of genetic engineering, the obtainment strategy involves the use of two different fragments of DNA known currently with the denominations of vector and passenger. The xenobiochemical peculiarities of recombinant DNA formation explain the transgenesis process, specific for the recombinant DNA technology. The consequence of transgenesis consists in the modification of genotype and subsequently, of the phenotype. At the level of molecular biology it can be discussed as a phenomenon that influences the series of processes replication-transcription-translation. This series reveals that, at the end, the protein synthesis is also influenced. In modern biotechnologies these aspects can explain (positive and negative) effects induced by transgenesis in the conditions of a xenobiochemical conditioning. In this frame – approaching xenobiochemical aspects (regarding foreign DNA) – it becomes possible in recombinant DNA technology to discuss about genetically modified organisms (GMO) and the necessity to extend investigations over the polyheteronucleotidic sequences from DNA’s macromolecule.
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