The impact of the administration of sodium nitrate on hepatic metallograms of rabbits was evaluated using the atomic absorption spectrophotometry technique. The experimental model created in order to evaluate the effects of nitrates on the biochemical homeostasis, regarding especially the variations of some macro- and trace elements in liver, was based on the administration of sodium nitrate by drinking water in high concentrations related to the established value of maximum contaminant level (MCL). The investigation followed the effects of sodium nitrate (NaNO3) administration on two groups of rabbits in concentrations of 20 x MCL and 40 x MCL. The analytical determinations underline the effects of nitrates on biochemical homeostasis of macroelements (Na, K, Ca, Mg) and trace elements (Zn, Fe, Cu, Mn) by determination of their concentrations in thes liver of rabbits.