Investigation of Neurotoxic Effects of Al(III) on Neuronal and Glial Cells Through N-Methyl D-Aspartic Acid Receptors

Christiane Nday, Alison J. Drysdale, Bettina Platt, Α. Salifoglou
Ν-methyl D-aspartic acid (NMDA) is one of the five known stimulating amino acid receptor categories, which consist of chemical regulators of Ca(ΙΙ) channels on neurocellular membranes, playing an important role in memory process. What kind of metallotoxin effects, however, can affect the NMDA function of neuronal cells? We investigated the potential biological activity of well-characterized Al(III) forms in neuronal and glial cellular environment. This effort constitutes a challenge, because of the neurotoxic potential of the metal interacting with the cellular receptors and the evidence linking aluminum to Alzheimer Disease.
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