Control charts are ideal for daily routine analyses. The chart shows the (assumed) relation with the normal distribution of the data around the mean. The interpretation and practical use of control charts is based on a number of rules derived from the probability statistics of the normal distribution. The results of analyses of reference material analysed with each batch of samples indicate whether the errors fall within acceptable limits. Several causes might cause systematic and random errors in analyte assays. The analytical system is under control and the results of a batch can be accepted when a control result falls within a distance of 2SD from the mean.