Adducts Of Deoxyribo-nucleic Acid with Nitrosamines

G.D. Ghibu, Gabriela Gârban, Z. Gârban
Chemical and physico-chemical investigations initiated during the 6th decade of the 20th century on the compounds resulted from the interaction between the DNA macromolecule and small molecules led to the idea of appearance of some bioincompatible structures that, at the beginning were named “molecular complexes”, an inadequate denomination because such compounds exist in chemistry and inorganic biochemistry. It was also used the term “molecular associations”, but it does not explain the existence of such compounds. During years of physical-chemical investigations and mechanic-quantum calculations over the electronic density in the donor-acceptor relationship between DNA and small molecules, the term “adducts” was preferred. This term is used in the present paper following the biogenesis of adducts of DNA with nitrosamines. Nitrosamines are compounds that can exert oncogenic effect due to their ability to form nucleophilic metabolites that binds especially to DNA nucleobases.
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