Călin Jianu, Adrian Riviş, Teodor Traşcă, Adelina Jianu, Gabriel Bujanca
Volume 20, Issue 4;
ISSN: 2069-0053 (print) (former ISSN: 1453-1399), Agroprint;
ISSN (online): 2068-9551
In a previous work we have proposed a synergic optimization of synthetical colloidal basic parameters (“homogeneous” cumulated degree by oligomerisation) (nCB) and cumulated hydrophile/hydrophobe values HLBCB) of certain homogeneous conjugates PEGn-L(2R’; R) (R’; 2R) (I) (structured by Williamson procedure) “colloidally disadvantage” (HLB = 2–7) through gradual binary association (1–70 % initially with “homogeneous” polyoxyethylene chains with (n = 3, 9, 18, 30, 40, 50) monoderivatized R(EH) and afterwards conjugates PEGn-L(2R’;R) (R’;2R) ”colloidally advantaged” (HLB = 9–13).
Encouraging results obtained suggested the idea of extending colloidal association systems from the binary to the ternary association, because operating range and degrees of liberty ensure the possibility of controlled modification a whole lot more extended.
To this purpose, there has by “homogeneous” conjugates PEGn-L (2R’; R) (R’; 2R) HLB1/HLB2/HLB3 = 2/6/13; 2/8/13; 2/10/13; 6/8/13; 6/10/13; 8/10/13 in gradual percentage ratios for each mentioned series by 10/34/56; 20/34/46; 33/34/33; 50/34/16; 60/34/6 for which it was assessed the evolution of the ternary cumulated “homogeneous” degree of oligomerisation (nCT) and the ternary cumulated hydrophile/hydrophobe values (HLBCT).
lt has been considered as a work premise, later on verified, the previous statement according to which hydrocarbonate chains R’ and/or R only contributes insignificantly in the modification of the colloidal competences range.
cumulated colloidal competences, ternary colloidal systems, polyoxyethylene conjugates, PEG-ylated lipids, structurated lipidic architectures